Move over, Profhilo; a new injectable is being heralded as a game-changer in aesthetics. Like Profhilo and other skin boosters, Polynucleotides deliver more youthful, radiant skin without changing the face’s shape or movement, which happens with dermal fillers and anti-wrinkle injections. Furthermore, Polynucleotides have regenerative powers, so they encourage the skin to ‘act’ younger or can be used to treat specific skin conditions such as acne scarring.
Although they are described as the next big thing, Polynucleotides have been used in tissue and cartilage regenerative medicine for 40 years and have been used medically in treating scarring and inflammatory skin conditions such as severe eczema.
What are Polynucleotides?
Polynucleotides are chains of nucleotides, the building blocks of DNA and RNA. These long chains play a crucial role in the genetic makeup of living organisms, encoding the instructions for cellular functions. Specifically, Polynucleotide injections are derived from the DNA of salmon sperm, which is very similar to human DNA.
The use of Polynucleotides in aesthetics is rooted in their ability to support the natural skin regeneration processes. As we age, our skin’s ability to repair and renew itself diminishes, leading to fine lines, wrinkles, and a loss of elasticity.
They act like biostimulators when injected by ‘instructing’ the cells to increase the production of fibroblasts, producing collagen, elastin and hyaluronic acid. These naturally-occurring components in our skin keep it taut, lifted and hydrated. They also accelerate cellular turnover.
DNA repair and anti-ageing
One of the key promises of Polynucleotides is their potential to address signs of ageing at a genetic level. These chains of nucleotides are thought to aid in DNA repair, helping to reverse damage caused by environmental factors such as UV radiation and pollution. By promoting DNA repair mechanisms, Polynucleotides may contribute to a more youthful and resilient complexion.
What’s the difference between Polynucleotides and skin boosters?
Skin boosters such as Profhilo are thought to stimulate collagen regeneration. Still, this effect is relatively minimal, and its primary benefit is hydrating the skin rather than thickening skin density by kickstarting collagen and elastin production. Polynucleotides do this while hydrating the skin and fighting the damage caused by free radicals.
The other main difference is that hyaluronic acid skin boosters typically can only be applied in certain areas – the Profhilo BAP technique has five specific injection points on each side of the face: the upper cheek, nasal base, lower cheek, jawline, and chin.
Polynucleotides can be used all over the face and neck, including the bonier parts of the face, such as the cheekbones or jawline. It is safe to be used on the delicate skin under the eyes and around the lips and regenerating the skin on the knees, elbows, back of hands and décolletage. It is even used on the scalp to reverse hair loss.
A revolutionary approach to treating dark circles
By thickening the skin, Polynucleotides reduce the appearance of pigmentation, which becomes more noticeable as the skin naturally thins. It also improves the appearance of hollows, particularly the tear trough groove that forms between the mid-cheek and eye junction.
“Previously, dermal fillers have been used to treat the tear trough. However, the combination of the hydrophyllic or water-attracting nature of hyaluronic acid dermal fillers with the thin skin under the eyes can result in a less than satisfactory aesthetic outcome.
“I believe treating the tear trough with dermal fillers will become a thing of a past with the advent of polynucleotides,” concludes Dr Petillon.